BM Hyal Injection: Intra-articular Hyaluronic Acid Injection for Knee Osteoarthritis & Periarthritis of the shoulder

Product Overview

BM Hyal Injection is a sterile, viscoelastic solution of hyaluronic acid designed for intra-articular administration .
It helps relieve pain and improve joint mobility in patients with knee osteoarthritis or periarthritis of the shoulder by supplementing the synovial fluid and protecting the cartilage.

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Indications

• Knee osteoarthritis

• Periarthritis of the shoulder

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Dosage & Administration

• Adults: Inject one vial (one pre-filled syringe) into the affected joint once a week for 3 consecutive weeks .

• The dosage and frequency can be adjusted by the physician depending on the patient's condition and response.

• Administer intra-articularly into the knee or shoulder joint cavity under strict aseptic conditions.

• If no improvement is observed after three injections, treatment should be discontinued.

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Important Notes

Because BM Hyal is administered directly into the joint, it must be performed under strict aseptic technique by a healthcare professional .

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Precautions

Contraindications

Do not administer to:

• Patients with known hypersensitivity to hyaluronic acid or any component of the formulation.

Use with Caution in:

• Patients with a history of hypersensitivity to other medications.

• Patients with liver disorders or a history thereof (cases of elevated AST/ALT have been reported).

• Patients with skin disease or infection at the injection site.

Adverse Reactions

Serious

• Shock: Rare but possible. Patients should be monitored closely during and after the procedure. Discontinue immediately if symptoms occur and provide appropriate treatment.

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• Hypersensitivity: Facial or eyelid edema, facial flushing, rash, urticaria, pruritus.

• Injection site reactions: Transient pain, swelling, mild effusion, redness, warmth, severe localized pressure sensation.

• Others: Nausea, vomiting, fever.

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General Precautions

• If the joint has severe inflammation due to osteoarthritis, treat the inflammation first before administering BM Hyal.

• To avoid exacerbating local pain, advise the patient to rest the joint after injection.

• Ensure the injection is properly delivered into the joint cavity to prevent extra-articular pain.

• Do not inject into blood vessels or use for ophthalmic purposes.

• Avoid contact with disinfectants containing benzalkonium chloride, quaternary ammonium salts, or chlorhexidine as precipitation may occur.

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Special Populations

• Pregnancy & Lactation: Animal studies did not show teratogenic effects, but use only if the potential benefit justifies the potential risk. Hyaluronic acid may pass into breast milk; breastfeeding should be avoided during treatment.

• Children: Safety and efficacy in pediatric patients have not been established.

• Elderly: Use with caution as physiological functions may be reduced.

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管理ノート

• Use a 22–23G needle for injection.

• If joint effusion is present, aspirate the fluid before injection.

• Administer strictly intra-articularly — not intravenously or subcutaneously.

• If no symptom improvement is observed after three injections, discontinue treatment.