1) Efficacy, effect
○ Increased penetration when administered subcutaneously, intramuscularly, local anesthetic, or subcutaneously.
○ Promotes reabsorption of excess fluid and blood within tissues
2) Usage, dosage
1. Subcutaneous injection (mass subcutaneous injection)
Dissolve 1,500 IU of hyaluronidase in 1 mL of water for injection or saline solution and inject it into the relevant area before starting subcutaneous injection, or inject it into the tube about 2 cm above the injection needle when starting the injection. When administering 500 to 1,000 mL of fluid, 1,500 IU of this drug is appropriate. In children and the elderly, the rate of fluid administration and total dose should be carefully controlled, and especially in patients with renal impairment, caution should be taken to avoid fluid overload.
2. When administering subcutaneous or intramuscular injection
Use 1,500 IU of this drug by dissolving it directly in the injection solution to be administered.
3. Local anesthetic to administer approximately 1,500 IU
It is used by dissolving it in injection solution. When used in ophthalmology, a concentration of 15 IU per mL is recommended.
4. Extravasation: In cases where it is diffuse rather than localized, extravasation occurs.
After the condition appears, dissolve 1,500 IU of this drug in 1 mL of water for injection or saline solution and infiltrate the lesion site as soon as possible.
5. Hematoma
Dissolve 1,500 IU of this drug in 1 mL of water for injection or physiological saline injection and infiltrate the affected area.
Immediately before use, dissolve this drug in the injection solution to be administered with approximately 1 mL of water for injection.
The subcutaneous injection solution must be isotonic with the extracellular fluid of the body. This drug can be combined with commonly used intravenous solutions. Cases of large-scale subcutaneous injections using physiological saline injection, 0.18% sodium chloride, 4% glucose, 0.45% sodium chloride, 2.5% glucose, and 5% glucose injection have been reported.
Potassium is administered at 34 mmol/L in isotonic glucose or physiological saline injection.
Infusion solutions containing electrolytes are more suitable than infusion solutions that do not contain electrolytes, and should not be injected too quickly. This drug is used in combination with morphine, diamorphine, hydromorphine, chlorpromazine, metoclopramide, promazine, dexamethasone, local anesthetics, and epinephrine.
3) Packaging unit
10 vials/case
4) Ingredients, content
Hyaluronidase 1500 IU
5) Period of use
See details
6) Storage method
Sealed container, store at 1~25°C
